Non‐exponential growth of Mycobacterium leprae Thai‐53 strain cultured in vitro
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چکیده
منابع مشابه
Non‐exponential growth of Mycobacterium leprae Thai‐53 strain cultured in vitro
In this study, attempts were made to culture this bacterium in media supplemented with a variety of biological materials to determine why cultivation of Mycobacterium leprae in vitro has not this far been successful. A slight increase in the number of cells in medium supplemented with human blood plasma and an extract of nude mouse tissue as observed after more than 3 months of cultivation at 3...
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Macrophages were obtained from the peritoneal cavities of mice and infected in vitro with Mycobacterium leprae. After three weeks, the multiplication of the bacteria was observed inside of the infected cells. Three weeks after the infection the medium was replaced and antibiotic free medium was added to culture flask which was incubated at 32°C. Three months later, amorphous turbidity was obser...
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patient i s going to be awarded the highest overall grade) , the same information will continue to be reported, as a consequence of which the true impact of POD activities cannot be evaluated by mere inspection of records. The programme managers evaluating the reports will have no option but to screen the original records of the individual patients . This will often not be feasible, for obvious...
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The Thai-53 strain of Mycobacterium leprae has been widely utilised for many experiments as a type strain in leprosy research. – 3 However, the origin and history of the strain is not clearly understood by most researchers. This letter describes the history and some genomic characteristics of the Thai-53 strain. The bacilli were obtained from a biopsy sample of an LL patient in Thailand on 25th...
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In vitro susceptibility of Mycobacterium leprae to two bipyridyl analogs was studied by using two biochemical parameters to measure the metabolic activity of the organism. VUF-8514 at 0.16 micrograms/ml, but not VUF-8842, completely inhibited the metabolic activity of M. leprae, and the action was bactericidal. When compared to rifampin (MIC 0.3 micrograms/ml), VUF-8514 was equally bactericidal...
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ژورنال
عنوان ژورنال: Microbiology and Immunology
سال: 2016
ISSN: 0385-5600,1348-0421
DOI: 10.1111/1348-0421.12454